欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-TFF3 inhibitor AMPC
TFF3 inhibitor AMPC

Chemical Structure : TFF3 inhibitor AMPC

CAS No.: 2254434-33-6

加入收藏

TFF3 inhibitor AMPC (AMPC)

货号: PC-38711Not For Human Use, Lab Use Only.

AMPC is a first-in-class small-molecule inhibitor of the oncogenic functions of trefoil factor 3 (TFF3) that specifically monomerizes dimeric TFF3 to inhibit dimeric TFF3 function, specifically binds to Cys57 of TFF3.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3580 In stock
50 mg ￥5480 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AMPC is a first-in-class small-molecule inhibitor of the oncogenic functions of trefoil factor 3 (TFF3) that specifically monomerizes dimeric TFF3 to inhibit dimeric TFF3 function, specifically binds to Cys57 of TFF3.
AMPC treatment decreased TFF3 protein levels in a dose-dependent manner in BT474 cells, with a significant reduction of TFF3 levels at 10 uM, decreased HER1-4 phosphorylation and phosphorylation of downstream AKT and p44/42 MAPK in a dose-dependent manner.
AMPC exhibited cell growth inhibition against BT474 and MDA-MB-361 cells with IC50 of 1.2 and 3.7 uM, respectively.
AMPC inhibition of TFF3 decreased monolayer cell viability, increased apoptosis and decreased 3D Matrigel growth of trastuzumab resistant BT474 cells, without re-sensitization to trastuzumab.
AMPC exhibited synergistic inhibitory effects on lung ADC cell growth when combined with various MEK1/2 inhibitors.

物理化学性质&存储条件

分子量 425.419
分子式 C25H16FN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Amino-4-(4-(6-fluoro-5-methylpyridin-3-yl)phenyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile

参考文献

1. Chong QY, et al. Oncotarget. 2017;8:74188–74208.

2. Mengyi Zhang, et al. Oncogenesis. 2019 Nov 4;8(11):65.

3. Poh HM, et al. Cancers (Basel). 2019 Oct 10;11(10):1528.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: