TFEB activator 2 | TFEB activator | Probechem Biochemicals

Chemical Structure : TFEB activator 2

CAS No.: 3027414-04-3

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TFEB activator 2 (Compound 37)

货号: PC-28577Not For Human Use, Lab Use Only.

TFEB activator 2 is a brain penetrant small molecule activator of transcription factor EB (TFEB), promotes TFEB nuclear translocation and lysosome biogenesis by targeting the DAT-CDK9-TFEB pathway.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TFEB activator 2 is a brain penetrant small molecule activator of transcription factor EB (TFEB), promotes TFEB nuclear translocation and lysosome biogenesis by targeting the DAT-CDK9-TFEB pathway.
TFEB activator 2 alleviates AD-like symptoms in APP/PS1 mice by inducing lysosome biogenesis.
TFEB activator 2 reduces brain Aβ plaques and improves the memory of APP/PS1 mice.
TFEB activator 2 effectively improves learning, memory, and cognitive function in APP/PS1 mice via enhancing lysosome biogenesis and Aβ clearance.

物理化学性质&存储条件

分子量	436.53
分子式	C26H29FN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,3-Dioxolo[4,5-g]isoquinoline, 5-[2-(5-fluoro-1H-indol-3-yl)ethyl]-5,6,7,8-tetrahydro-6-[(tetrahydro-2H-pyran-4-yl)methyl]-

参考文献

1. Jianhui Zhou, et al. J Med Chem. 2024 Jun 13;67(11):8836-8861.

TFEB activator 2 (Compound 37)

生物&药学活性

物理化学性质&存储条件

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TFEB activator 2 (Compound 37)

生物&药学活性

物理化学性质&存储条件

参考文献

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