TET inhibitor C35 | TET inhibitor | Probechem Biochemicals

Chemical Structure : TET inhibitor C35

CAS No.: 98570-83-3

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TET inhibitor C35 (Phylloflavan, NSC 607319, Compound C35, TET-IN-C35)

货号: PC-72555Not For Human Use, Lab Use Only.

TET inhibitor C35 (Phylloflavan, NSC 607319, TET-IN-C35) is a first-in-class, highly potent, cell-permeable pan-TET inhibitor (TET2 IC50=1.2 uM) that specifically targets TET catalytic domain and reduces 5-hydroxymethylcytosine (5hmC) load on the genome.

规格	价格	库存
5 mg	￥3580	In stock
10 mg	￥5580	In stock
25 mg	￥9580	In stock
100 mg		Get quote

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生物&药学活性

TET inhibitor C35 (Phylloflavan, NSC 607319, TET-IN-C35) is a first-in-class, highly potent, cell-permeable pan-TET inhibitor (TET2 IC50=1.2 uM) that specifically targets TET catalytic domain and reduces 5-hydroxymethylcytosine (5hmC) load on the genome.
TET inhibitor C35 is a general TET inhibitor that targets all members of the TET family.
TET inhibitor C35 also suppresses the catalytic activities of TET1 and TET3 with IC50 3.48 uM and 2.31 uM, respectively.
TET inhibitor C35 treatment reduces genome-wide 5hmC level in human and mouse cells.
TET inhibitor C35 promotes somatic cell reprogramming induces the expression of members of the BMP-SMAD-ID axis.

物理化学性质&存储条件

分子量	498.484
分子式	C26H26O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenepentanoic acid, beta,3,4-trihydroxy-, (2R,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl ester, (betaS)-

参考文献

1. Anup Kumar Singh, et al. Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3621-3626.

TET inhibitor C35 (Phylloflavan, NSC 607319, Compound C35, TET-IN-C35)

生物&药学活性

物理化学性质&存储条件

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TET inhibitor C35 (Phylloflavan, NSC 607319, Compound C35, TET-IN-C35)

生物&药学活性

物理化学性质&存储条件

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