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首页-小分子抑制剂&激动剂-Others-Other Targets-TES-1025
TES-1025

Chemical Structure : TES-1025

CAS No.: 1883602-21-8

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TES-1025 (TES1025)

货号: PC-35239Not For Human Use, Lab Use Only.

TES-1025 (TES1025) is a potent, selective inhibitor of human ACMSD (α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase) with IC50 of 13 nM, increases NAD+ levels in cellular systems.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TES-1025 (TES1025) is a potent, selective inhibitor of human ACMSD (α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase) with IC50 of 13 nM, increases NAD+ levels in cellular systems.
TES-1025 demonstrates suitable overall balance of good physicochemical properties and in vitro safety profile.
TES-1025 modulates intracellular NAD+ levels with consequent in vivo enhancement of de novo NAD+ biosynthesis via ACMSD target engagement.

物理化学性质&存储条件

分子量 383.44
分子式 C18H13N3O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(3-(((5-cyano-6-oxo-4-(thiophen-2-yl)-1,6-dihydropyrimidin-2-yl)thio)methyl)phenyl)acetic acid

参考文献

1. Pellicciari R, et al. J Med Chem. 2018 Feb 8;61(3):745-759.

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