TERT inhibitor NU-1

Chemical Structure : TERT inhibitor NU-1

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货号: PC-20452Not For Human Use, Lab Use Only.

TERT inhibitor NU-1 is an irreversible telomerase reverse transcriptase (TERT), targets the non-homologous end joining (NHEJ) DSB repair pathway.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

TERT inhibitor NU-1 is an irreversible telomerase reverse transcriptase (TERT), targets the non-homologous end joining (NHEJ) DSB repair pathway.
NU-1 decreases cell viability in telomerase-positive human cancer cell lines, including breast cancer MCF7 (LD50=21 uM), impacts DNA damage pathway gene expression.
NU-1 enhances the chemo-sensitivity of telomerase-positive cancer cells.
NU-1 induces radiosensitivity and cellular senescence, induces persistent DNA damage foci and delays double-strand break repair after irradiation in telomerase-positive cells.
NU-1 dramatically enhanced the effects of radiation, leading to immune-dependent tumor elimination in CT26 tumors in BALB/c mice.

物理化学性质&存储条件

分子量	419.43
分子式	C21H23F2N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (2S,3R,6R)-2-(2-(1-(2,4-difluorobenzyl)-1H-1,2,3-triazol-4-yl)ethyl)-3,6-dimethyl-5-methylene-4-oxotetrahydro-2H-pyran-3-carboxylate

参考文献

1. Yue Liu, et al. Cell Chem Biol. 2022 Oct 20;29(10):1517-1531.e7.