TEI-8362 | Neutrophil elastase inhibitor | Probechem Biochemicals

Chemical Structure : TEI-8362

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TEI-8362 (TEI 8362)

货号: PC-49569Not For Human Use, Lab Use Only.

TEI-8362 (TEI 8362) is a potent, selective inhibitor of human neutrophil elastase (HNE) with Ki value of 1.38 nM and IC50 of 1.9 nM.

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生物&药学活性

TEI-8362 (TEI 8362) is a potent, selective inhibitor of human neutrophil elastase (HNE) with Ki value of 1.38 nM and IC50 of 1.9 nM.
TEI-8362 showed 1000-fold selectivity for HNE versus chymotrypsin, and 100 fold versus trypsin.
TEI-8362 (0.03, 0.10 and 0.30 mg/kg, intratracheal administration) inhibited acute lung haemorrhage in a dose-dependent manner on HNE-induced lung haemorrhage in hamsters with an ED50 of 45 ug/kg.
TEI-8362 (0.1, 1.0 and 10.0 mg/ kg, intratracheal administration) also inhibited acute lung haemorrhage and attenuated the increase in elastase-like activity in a dose-dependent manner in LPS and FMLP-induced acute lung injury in hamsters with an ED50 of 0.56 mg/kg.

物理化学性质&存储条件

分子量	540.529
分子式	C26H28N4O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(N-(3-((3-carboxypropyl)amino)-8-methyl-1-oxo-4-azaisochromen-6- yl)carbamoyl)-4-((phenylmethoxy)carbonylamino)butanoic acid

参考文献

1. Mitsuhashi H, et al. Br J Pharmacol. 1999 Mar;126(5):1147-52.

TEI-8362 (TEI 8362)

生物&药学活性

物理化学性质&存储条件

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TEI-8362 (TEI 8362)

生物&药学活性

物理化学性质&存储条件

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