TED-347 | YAP-TEAD4 inhibitor | Probechem Biochemicals

Chemical Structure : TED-347

CAS No.: 2378626-29-8

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TED-347 (TED347)

货号: PC-35898Not For Human Use, Lab Use Only.

TED-347 (TED347) is an irreversible inhibitor of TEAD4-Yap1 protein-protein interaction (EC50=5.9 uM in FP asssays) via covalent modification of conserved cysteine (Cys367, Ki=1.3 uM), inhibits its binding to Yap1, blocked its transcriptional activity.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

TED-347 (TED347) is an irreversible inhibitor of TEAD4-Yap1 protein-protein interaction (EC50=5.9 uM in FP asssays) via covalent modification of conserved cysteine (Cys367, Ki=1.3 uM).
TED-347 inhibits its binding to Yap1, blocked its transcriptional activity; inhibits TEAD transcriptional activity and protein interactions in cells at 5 uM resulted in over 70% reduction in reporter activity.
TED-347 inhibits GBM43 cancer cell viability by 30% at 10 uM, also inhibits TEAD4 transcriptional activity in GBM43 cells.

物理化学性质&存储条件

分子量	313.704
分子式	C15H11ClF3NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-1-(2-((3-(trifluoromethyl)phenyl)amino)phenyl)ethan-1-one

参考文献

1. Bum-Erdene K, et al. Cell Chem Biol. 2018 Dec 18. pii: S2451-9456(18)30432-X.

TED-347 (TED347)

生物&药学活性

物理化学性质&存储条件

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TED-347 (TED347)

生物&药学活性

物理化学性质&存储条件

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