TEAD activator Q2 | TEAD activator | Probechem Biochemicals

Chemical Structure : TEAD activator Q2

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TEAD activator Q2 (Quinolinol Q2)

货号: PC-20409Not For Human Use, Lab Use Only.

TEAD activator Q2 (Quinolinol Q2) is a small molecule activator of TEAD with EC50 of 2.6 uM in TEAD dual-luciferase reporter (DLR) assays, inhibits TEAD-palmitate interaction with IC50 of 1.7 uM.

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生物&药学活性

TEAD activator Q2 (Quinolinol Q2) is a small molecule activator of TEAD with EC50 of 2.6 uM in TEAD dual-luciferase reporter (DLR) assays, inhibits TEAD-palmitate interaction with IC50 of 1.7 uM.
Quinolinol Q2 directly binds to TEAD with SPR Kd of 2.6 uM, significantly enhances the expression levels of YAP/TAZ-TEAD target genes.
Quinolinol Q2 accelerates cutaneous wound healing in mice, activates nuclear YAP and enhances cell proliferation within days 4-5 postwounding.

物理化学性质&存储条件

分子量	349.43
分子式	C21H23N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((4-(dimethylamino)phenyl)(8-hydroxyquinolin-7-yl)methyl)propionamide

参考文献

1. Ajaybabu V Pobbati, et al. ACS Chem Biol. 2019 Dec 20;14(12):2909-2921.

TEAD activator Q2 (Quinolinol Q2)

生物&药学活性

物理化学性质&存储条件

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TEAD activator Q2 (Quinolinol Q2)

生物&药学活性

物理化学性质&存储条件

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