TDRL-551 | RPA inhibitor | Probechem Biochemicals

Chemical Structure : TDRL-551

CAS No.: 1644626-43-6

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TDRL-551 (TDRL551, Replication Protein A inhibitor)

货号: PC-20337Not For Human Use, Lab Use Only.

TDRL-551 (TDRL551) is a small molecule Replication Protein A (RPA) inhibitor targeting the Replication Protein A-DNA interaction with IC50 of 18 uM.

规格	价格	库存
5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TDRL-551 (TDRL551) is a small molecule Replication Protein A (RPA) inhibitor targeting the Replication Protein A-DNA interaction with IC50 of 18 uM.
TDRL-551 exhibits single agent anti-cancer activity in the A2780 EOC cell line using clonogenic survival assays with IC50 of 25 uM.
TDRL-551 is synergistic with DNA damaging chemotherapeutic agent in platinum sensitive A2780 cell line.
TDRL-551 displays single agent anti-cancer activity and sensitizes NSCLC tumors to platinum based treatment in vivo.

物理化学性质&存储条件

分子量	591.83
分子式	C25H23ClIN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(2-Chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-1H-pyrazole-1-pentanoic acid

参考文献

1. Mishra AK, et al. Biochem Pharmacol. 2015 Jan 1;93(1):25-33.

2. Gavande NS, et al. ACS Med Chem Lett. 2020 Jan 2;11(6):1118-1124.

TDRL-551 (TDRL551, Replication Protein A inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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TDRL-551 (TDRL551, Replication Protein A inhibitor)

生物&药学活性

物理化学性质&存储条件

参考文献

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