TDP-665759 |CAS:787632-66-0 Probechem Biochemicals

Chemical Structure : TDP-665759

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TDP-665759 (TDP665759;TDP 665759)

货号: PC-60439Not For Human Use, Lab Use Only.

TDP-665759 is a small molecule inhibitor of HDM2-p53 interaction with FP IC50 of 0.7 uM.

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生物&药学活性

TDP-665759 is a small molecule inhibitor of HDM2-p53 interaction with FP IC50 of 0.7 uM.
TDP-665759 inhibits the proliferation of wt p53-expressing cell lines with average IC50 of 0.7 uM, stabilizes p53 protein levels, upregulates p53 target genes in a DNA damage-independent manner, and induces apoptosis in HepG2 cells.
TDP-665759 increases p21(waf1/cip1) levels in mice liver samples, synergizes the effect of doxorubicin both in culture and in an A375 xenograft model.

物理化学性质&存储条件

分子量	706.45
分子式	C31H34Cl2IN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-4-[(1R)-1-(2-Amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-3,4-dihydro-7-iodo-1-[3-(4-methyl-1-piperazinyl)propyl]-1H-1,4-benzodiazepine-2,5-dione

参考文献

1. Koblish HK, et al. Mol Cancer Ther. 2006 Jan;5(1):160-9.

TDP-665759 (TDP665759;TDP 665759)

生物&药学活性

物理化学性质&存储条件

参考文献

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TDP-665759 (TDP665759;TDP 665759)

生物&药学活性

物理化学性质&存储条件

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