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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-TDI-11904
TDI-11904

Chemical Structure : TDI-11904

CAS No.: 3056015-44-9

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TDI-11904 (TDI 11904)

货号: PC-72366Not For Human Use, Lab Use Only.

TDI-11904 is a highly potent, and peripherally active EZH2 inhibitor with IC50 of 0.9 nM, inhibits H3K27me3 with IC50 of 6.0 nM in cellular EZH2 inhibition assay.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TDI-11904 is a highly potent, and peripherally active EZH2 inhibitor with IC50 of 0.9 nM, inhibits H3K27me3 with IC50 of 6.0 nM in cellular EZH2 inhibition assay.

    物理化学性质&存储条件

    分子量 507.430
    分子式 C23H24Cl2N4O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6,9-dichloro-7-(3,5-dimethylisoxazol-4-yl)-1-methyl-4-((6-methyl-4-(methylthio)-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one

    参考文献

    1. Rui Liang, et al. ACS Med Chem Lett. 2022 Feb 10;13(3):377-387.

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