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首页-小分子抑制剂&激动剂-Others-Other Targets-TD-198946
TD-198946

Chemical Structure : TD-198946

CAS No.: 364762-86-7

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TD-198946 (TD198946)

货号: PC-23673Not For Human Use, Lab Use Only.

TD-198946 is a small molecule disease-modifying osteoarthritis compound, effectively repairs cartilage by promoting chondrogenic differentiation and halt osteoarthritis (OA) progression, exerts its effect through the regulation of Runx1 expression.

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10 mg ￥2780 In stock
25 mg ￥4580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TD-198946 is a small molecule disease-modifying osteoarthritis compound, effectively repairs cartilage by promoting chondrogenic differentiation and halt osteoarthritis (OA) progression, exerts its effect through the regulation of Runx1 expression.
TD-198946 strongly induced chondrogenic differentiation without promoting hypertrophy in cell and metatarsal organ cultures.
TD-198946 prevented and repaired degeneration of the articular cartilage. 
TD-198946 (>1 nM) dose-dependently enhanced glycosaminoglycan (GAG) production, particularly hyaluronan, whereas chondrocyte differentiation was not impacted.
When combined with transforming growth factor β3 (TGFβ3), TD-198946 promoted chondrocyte differentiation and production of cartilaginous matrices at doses <1 nM as judged by SOX9, S100, and type 2 collagen upregulation.

物理化学性质&存储条件

分子量 482.56
分子式 C27H22N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Methyl-8-(4-(quinolin-2-ylmethoxy)phenoxy)-4,5-dihydro-1H-thieno[3,4-g]indazole-6-carboxamide

参考文献

1. Yano F, et al. Ann Rheum Dis. 2013 May;72(5):748-53.

2. Chijimatsu R, et al. J Tissue Eng Regen Med. 2019 Mar;13(3):446-458.

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