Izencitinib (TD-1473, JNJ 8398) | Pan-JAK inhibitor | Probechem Biochemicals

Chemical Structure : TD-1473

CAS No.: 2051918-33-1

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TD-1473 (Izencitinib, TD1473, JNJ 8398)

货号: PC-72341Not For Human Use, Lab Use Only.

TD-1473 (Izencitinib, TD1473, JNJ 8398) is a potent, selective, oral gut-selective pan-JAK inhibitor with pKi of 10.0/10.0/8.8/9.5 for human recombinant JAK1, JAK2, JAK3 and TYK2.

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5 mg	￥2280	In stock
10 mg	￥3580	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

TD-1473 (Izencitinib, TD1473, JNJ 8398) is a potent, selective, oral gut-selective pan-JAK inhibitor with pKi of 10.0/10.0/8.8/9.5 for human recombinant JAK1, JAK2, JAK3 and TYK2.
TD-1473 inhibited cytokine-induced phosphorylation of STAT1 in mouse primary colonic epithelial cells with pIC50 values for inhibition against IL-6, IFNα and IFNγ were 7.3, 6.8 and 7.0.
TD-1473 demonstrated JAK inhibitory activity in ex vivo mouse colon and human IBD patient colonic tissue.
TD-1473 (Izencitinib) is under development for the treatment of ulcerative colitis.

物理化学性质&存储条件

分子量	402.506
分子式	C22H26N8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((1R,3S,5S)-3-((7-((5-Methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile

参考文献

1. Sandborn WJ, et al. J Crohns Colitis. 2020 Sep 16;14(9):1202-1213.

2. Hardwick RN, et al. Toxicol Sci. 2022 Feb 4:kfac002.

TD-1473 (Izencitinib, TD1473, JNJ 8398)

生物&药学活性

物理化学性质&存储条件

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TD-1473 (Izencitinib, TD1473, JNJ 8398)

生物&药学活性

物理化学性质&存储条件

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