TD-1 | Hemoglobin modulator | Probechem Biochemicals

Chemical Structure : TD-1

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TD-1 (Hemoglobin modulator TD-1)

货号: PC-62380Not For Human Use, Lab Use Only.

Hemoglobin modulator TD-1 (TD-1) is a novel allosteric effector of hemoglobin that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling.

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生物&药学活性

Hemoglobin modulator TD-1 (TD-1) is a novel allosteric effector of hemoglobin that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling.
TD-1 increases the oxygen affinity of sickle hemoglobin and inhibits in vitro hypoxia-induced sickling of red blood cells in patients with sickle cell disease without causing hemolysis.
TD-1 is a novel lead molecule for the treatment of patients with sickle cell disease.

物理化学性质&存储条件

分子量	468.506
分子式	C20H16N6O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Di(5-(2,3-dihydro-1,4-benzodioxin-2-yl)-4H-1,2,4-triazol-3-yl)disulfide

参考文献

1. Nakagawa A, et al. ACS Chem Biol. 2014 Oct 17;9(10):2318-25.

TD-1 (Hemoglobin modulator TD-1)

生物&药学活性

物理化学性质&存储条件

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TD-1 (Hemoglobin modulator TD-1)

生物&药学活性

物理化学性质&存储条件

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