TCV-309 | PAF inhibitor | ProbeChem Biochemicals

Chemical Structure : TCV-309

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TCV-309 (TCV 309, TCV309)

货号: PC-70117Not For Human Use, Lab Use Only.

TCV-309 is a highly potent and selective platelet activating factor (PAF) antagonist, inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively.

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生物&药学活性

TCV-309 is a highly potent and selective platelet activating factor (PAF) antagonist, inhibits PAF-induced aggregation of rabbit and human platelets with IC50s of 33 nM and 55 nM respectively.
TCV-309 potently protects mice from death induced by PAF and due to anaphylactic shock with ED50 of 2.1 and 2.6 ug/kg (i.v.), respectively.
TCV-309 also reverses PAF-induced hypotension and endotoxin-induced hypotension in rats.

物理化学性质&存储条件

分子量	656.534
分子式	C30H34BrN5O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-bromo-5-((3-oxo-3-((2-((1,2,3,4-tetrahydroisoquinoline-2-carbonyl)oxy)ethyl)amino)propyl)(phenyl)carbamoyl)-1-propylpyridin-1-ium nitrate

参考文献

1. Terashita Z, et al. J Pharmacol Exp Ther. 1992 Feb;260(2):748-55.

2. Motoyama N, et al. Eur J Pain. 2013 Sep;17(8):1156-67.

3. Kuipers B, et al. J Immunol. 1994 Mar 1;152(5):2438-46.

TCV-309 (TCV 309, TCV309)

生物&药学活性

物理化学性质&存储条件

参考文献

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TCV-309 (TCV 309, TCV309)

生物&药学活性

物理化学性质&存储条件

参考文献

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