TCS401 |CAS:243966-09-8 Probechem Biochemicals

Chemical Structure : TCS401

CAS No.: 243966-09-8

加入收藏

TCS401 (TCS-401, TCS 401)

货号: PC-42970Not For Human Use, Lab Use Only.

TCS-401 (TCS401) is a potent, selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) with Ki of 0.29 uM, weakly inhibits the protein phosphatases CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1, and LAR D1D2 with Ki of 59, 560, 1,100, >2,000, >2,000, and >2,000 uM.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TCS-401 (TCS401) is a potent, selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) with Ki of 0.29 uM, weakly inhibits the protein phosphatases CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1, and LAR D1D2 with Ki of 59, 560, 1,100, >2,000, >2,000, and >2,000 uM.
TCS-401 dose dependently inhibits the RPTC-Sup-induced reduction of fibronectin and α-SMA.
TCS-401 reduces RPTC-Sup-induced EGFR dephosphorylation and reverses the levels of fibronectin and α-SMA in renal fibroblasts.

物理化学性质&存储条件

分子量	306.7227
分子式	C10H11ClN2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 11 mg/mL
Chemical Name/SMILES	Thieno[2,3-c]pyridine-3-carboxylic acid, 2-[(carboxycarbonyl)amino]-4,5,6,7-tetrahydro-, hydrochloride (1:1)

参考文献

1. Iversen LF, et al. J Biol Chem. 2000 Apr 7;275(14):10300-7.

2. Ponnusamy M, et al. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F698-709.

3. Du ZD, et al. Mol Vis. 2015 May 1;21:523-31. eCollection 2015.

TCS401 (TCS-401, TCS 401)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TCS401 (TCS-401, TCS 401)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.