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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Proteasome-TCL-Ester
TCL-Ester

Chemical Structure : TCL-Ester

CAS No.:

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TCL-Ester (TCL-1 Ester)

货号: PC-21189Not For Human Use, Lab Use Only.

TCL-Ester is the cell-permeable derivative of TCL-1, a non-covalent ligand targeting the Pru domain of Rpn-13.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TCL-Ester is the cell-permeable derivative of TCL-1, a non-covalent ligand targeting the Pru domain of Rpn-13.
TCL-Ester (25-50 uM, 24 h) is toxic against hematological cancer cell lines that are sensitive to proteasome inhibition.
TCL-Ester is a useful scaffold can be modified and still retain binding to Rpn-13's Pru domain.

物理化学性质&存储条件

分子量 505.82
分子式 C21H18BrClN4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl 2-(3-(4-bromobenzyl)-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl)acetate

参考文献

1. Loy CA, et al. Bioorg Med Chem Lett. 2023 Sep 13:129485.

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