TCL-1 | Rpn-13 inhibitor | Probechem Biochemicals

Chemical Structure : TCL-1

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货号: PC-21188Not For Human Use, Lab Use Only.

TCL-1 is non-covalent inhibitor of the Pru (Pleckstrin-like receptor for ubiquitin) domain of Rpn-13, affects proteasome-mediated proteolysis.

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TCL-1 is non-covalent inhibitor of the Pru (Pleckstrin-like receptor for ubiquitin) domain of Rpn-13, affects proteasome-mediated proteolysis.

TCL-1 is shown to bind to the same surface as Rpn-2, which is a Rpn-13 binding partner within the 19S RP, with modest affinity (KD = 26 μM).

TCL-1 affects proteasome-mediated proteolysis through an interaction with Rpn-13.

分子量	477.76
分子式	C19H14BrClN4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-(4-bromobenzyl)-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl)acetic acid

1. Loy CA, et al. Bioorg Med Chem Lett. 2023 Sep 13:129485.