TCH-165 |CAS:1446350-60-2 Probechem Biochemicals

Chemical Structure : TCH-165

CAS No.: 1446350-60-2

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TCH-165 (TCH165)

货号: PC-35491Not For Human Use, Lab Use Only.

TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation.

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10 mg	￥4280	In stock
25 mg	￥7280	In stock
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生物&药学活性

TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation.
TCH-165 enhances the degradation of both α-syn and tau, does not induce the degradation of GAPDH, enhances the degradation of intrinsically disordered proteins in cell culture.
TCH-165 display a decrease in assembled 26S and an increase in 20S proteasome in treated cells.

物理化学性质&存储条件

分子量	595.743
分子式	C39H37N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (4R,5R)-1-benzyl-5-(4-(benzylamino)phenyl)-2-(4-methoxyphenyl)-4-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate

参考文献

1. Njomen E, et al. Biochemistry. 2018 Jul 17;57(28):4214-4224.

2. Azevedo LM, et al. J Med Chem. 2013 Jul 25;56(14):5974-8.

TCH-165 (TCH165)

生物&药学活性

物理化学性质&存储条件

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TCH-165 (TCH165)

生物&药学活性

物理化学性质&存储条件

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