TCASK10 |CAS:1005775-56-3 Probechem Biochemicals

Chemical Structure : TCASK10

CAS No.: 1005775-56-3

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TCASK10 (TCASK 10)

货号: PC-35394Not For Human Use, Lab Use Only.

TCASK10 is a potent, highly specific inhibitor of ASK1 with IC50 of 14 nM, 30-fold selectivity over ASK2 (IC50=510 nM) and no activity against MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf.

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5 mg	￥1580	In stock
10 mg	￥2580	In stock
25 mg	￥4580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TCASK10 is a potent, highly specific inhibitor of ASK1 with IC50 of 14 nM, 30-fold selectivity over ASK2 (IC50=510 nM) and no activity against MEKK1, TAK1, IKKβ, ERK1, JNK1, p38α, GSK-3β, PKCθ and B-raf.
TCASK10 blocks downstream JNK1/p38 phosphorylation in cells, dose-dependently reduces mitogen (FBS, PDGF and EGF)-induced airway smooth muscle (ASM) growth.
TCASK10 also prevents TGFb1-induced migration of ASM cells in vitro.

物理化学性质&存储条件

分子量	432.349
分子式	C21H23Cl2N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(1,1-Dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride

参考文献

1. Terao Y, et al. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7326-9.

2. Eapen MS, et al. Clin Sci (Lond). 2018 Jul 13. pii: CS20180398.

TCASK10 (TCASK 10)

生物&药学活性

物理化学性质&存储条件

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TCASK10 (TCASK 10)

生物&药学活性

物理化学性质&存储条件

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