TC14012 | ACKR3 agonist | Probechem Biochemicals

Chemical Structure : TC14012

CAS No.: 368874-34-4

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TC14012 (TC 14012)

货号: PC-22932Not For Human Use, Lab Use Only.

TC14012 is a selective and peptidomimetic CXCR4 antagonist with IC50 of 19.3 nM, also is a specific CXCR7 (ACKR3) agonist with EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7.

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生物&药学活性

TC14012 is a selective and peptidomimetic CXCR4 antagonist with IC50 of 19.3 nM, also is a specific CXCR7 (ACKR3) agonist with EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7.
TC14012 antagonizes the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells.
TC14012 significantly recruited β-arrestin to CXCR7 in CXCR7-expressing cells and activated extracellular signal-regulated kinase (ERK) in neonatal rat cardiomyocytes.

物理化学性质&存储条件

分子量	2066.43
分子式	C90H140N34O19S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Argininamide, L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-N5-(aminocarbonyl)-D-ornithyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-, cyclic (4→13)-disulfide

参考文献

1. Burger M, et al. Blood. 2005 Sep 1;106(5):1824-30.

2. Gravel S, et al. J Biol Chem. 2010 Dec 3;285(49):37939-43.

3. Ishizuka M, et al. Sci Rep. 2021 Feb 9;11(1):3426.

TC14012 (TC 14012)

生物&药学活性

物理化学性质&存储条件

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TC14012 (TC 14012)

生物&药学活性

物理化学性质&存储条件

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