TC13172 | MLKL inhibitor | Probechem Biochemicals

Chemical Structure : TC13172

CAS No.: 2093393-05-4

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TC13172 (TC 13172)

货号: PC-21158Not For Human Use, Lab Use Only.

TC13172 (TC 13172) is a highly potent necroptosis inhibitor targeting the mixed lineage kinase domain-like protein (MLKL), inhibits necroptosis with IC50 of 2 nM in TSZ-induced necroptosis assays in HT-29 cells.

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10 mg	￥3980	In stock
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生物&药学活性

TC13172 (TC 13172) is a highly potent necroptosis inhibitor targeting the mixed lineage kinase domain-like protein (MLKL), inhibits necroptosis with IC50 of 2 nM in TSZ-induced necroptosis assays in HT-29 cells.
TC13172 (10 uM) does not inhibit the kinase activities of RIP1 or RIP3 in in vitro assays.
TC13172 covalently binds MLKL at Cys-86, blocks the oligomerization and translocation of MLKL from the cytoplasm to the cell membrane.
TC13172 does not disrupt the phosphorylation of MLKL, but decrease the level of MLKL in the membrane phase.

物理化学性质&存储条件

分子量	388.40
分子式	C17H16N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(3-Hydroxyphenyl)prop-2-yn-1-yl)-1,7-dimethyl-8-(methylsulfonyl)-3,7-dihydro-1H-purine-2,6-dione

参考文献

1. Yan B, et al. Chem Commun (Camb). 2017 Mar 28;53(26):3637-3640.

TC13172 (TC 13172)

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物理化学性质&存储条件

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TC13172 (TC 13172)

生物&药学活性

物理化学性质&存储条件

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