TC-N1752 | NaV1.7 inhibitor | Probechem Biochemicals

Chemical Structure : TC-N1752

CAS No.: 1211866-85-1

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TC-N1752 (TC-N 1752)

货号: PC-27183Not For Human Use, Lab Use Only.

TC-N1752 is a potent, state-dependent and orally active inhibitor of voltage gated sodium channel Nav1.7 with IC50 of 0.17 uM, 0.3 uM, 0.4 uM, 1.1 uM and 2.2 uM for hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively, displays analgesic efficacy in the formalin pain model.

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生物&药学活性

TC-N1752 is a potent, state-dependent and orally active inhibitor of voltage gated sodium channel Nav1.7 with IC50 of 0.17 uM, 0.3 uM, 0.4 uM, 1.1 uM and 2.2 uM for hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively, displays analgesic efficacy in the formalin pain model.

物理化学性质&存储条件

分子量	516.53
分子式	C25H27F3N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-Methyl-3-((4-(4-((4-(trifluoromethoxy)benzyl)oxy)piperidin-1-yl)-1,3,5-triazin-2-yl)amino)phenyl)acetamide

参考文献

1. Howard Bregman, et al. J Med Chem. 2011 Jul 14;54(13):4427-45.

TC-N1752 (TC-N 1752)

生物&药学活性

物理化学性质&存储条件

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TC-N1752 (TC-N 1752)

生物&药学活性

物理化学性质&存储条件

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