TC-I 15 | α2β1 integrin inhibitor | Probechem Biochemicals

Chemical Structure : TC-I 15

CAS No.: 916734-43-5

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TC-I 15 (TC-I-15, α2β1 integrin inhibitor 15)

货号: PC-62071Not For Human Use, Lab Use Only.

TC-I 15 is a highly potent, selective, allosteric small-molecule inhibitor of integrin α2β1 with IC50 of 12 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

TC-I 15 is a highly potent, selective, allosteric small-molecule inhibitor of integrin α2β1 with IC50 of 12 nM.
TC-I 15 inhibits adhesion of cells expressing wild-type (WT) and demonstrates no effect on RBL cells expressing an activating I-domain mutation (E318A).
TC-I 15 inhibits an activating cytoplasmic domain mutant [Del(GFFKR)] with an IC50 ≈4-fold higher than for wild-type integrin α2β1.
TC-I 15 shows efficacious activity in an animal model of arterial thrombosis.

物理化学性质&存储条件

分子量	520.619
分子式	C23H28N4O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(3-benzylureido)-2-((R)-5,5-dimethyl-3-(phenylsulfonyl)thiazolidine-4-carboxamido)propanoic acid

参考文献

1. Miller MW, et al. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):719-24.

TC-I 15 (TC-I-15, α2β1 integrin inhibitor 15)

生物&药学活性

物理化学性质&存储条件

参考文献

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TC-I 15 (TC-I-15, α2β1 integrin inhibitor 15)

生物&药学活性

物理化学性质&存储条件

参考文献

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