TC-E 5005 | PDE10A inhibitor | Probechem Biochemicals

Chemical Structure : TC-E 5005

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TC-E 5005 (TCE-5005, TC-E-5005)

货号: PC-61347Not For Human Use, Lab Use Only.

TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 of 7.28 nM.

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生物&药学活性

TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 of 7.28 nM.
TC-E 5005 displays 30-500-fold selectivity over PDE10A, 2A, 11A, 5A, 7B and 3A, shows no inhibitory activity for PDE1B, 4A, 6, 8A and 9A (IC50>5 uM).
TC-E 5005 reverses stereotypy and hyperactivity induced by MK-801 in rats.
TC-E 5005 also inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate, inhibits neurogenic contractions with similar efficacy than tadalafil.

物理化学性质&存储条件

分子量	270.33
分子式	C15H18N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine

参考文献

1. Höfgen N, et al. J Med Chem. 2010 Jun 10;53(11):4399-411.

2. Hennenberg M, et al. Prostate. 2016 Nov;76(15):1364-74.

TC-E 5005 (TCE-5005, TC-E-5005)

生物&药学活性

物理化学性质&存储条件

参考文献

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TC-E 5005 (TCE-5005, TC-E-5005)

生物&药学活性

物理化学性质&存储条件

参考文献

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