TC-E 5003 | PRMT1 inhibitor | Probechem Biochemicals

Chemical Structure : TC-E 5003

CAS No.: 17328-16-4

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TC-E 5003 (TC-E5003)

货号: PC-49020Not For Human Use, Lab Use Only.

TC-E 5003 is a selective inhibitor of arginine methyltransferase I (PRMT1) with IC50 of 1.5 uM, does not inhibit PRMT4 or the lysine methyltransferase Set7/9.

规格	价格	库存
50 mg	￥680	In stock
100 mg	￥1180	In stock
250 mg	￥1980	In stock
1 g		Get quote

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生物&药学活性

TC-E 5003 is a selective inhibitor of arginine methyltransferase I (PRMT1) with IC50 of 1.5 uM, does not inhibit PRMT4 or the lysine methyltransferase Set7/9.
TC-E 5003 reduces the expression of inducible NO synthase (iNOS) and expressions of COX-2, TNF-α, IL-1β and IL-6 in RAW264.7 cells.
TC-E 5003 regulates LPS-induced AP-1 transcriptional activity by modulating the c-Jun gene expression.
TC-E 5003 downregulates the nuclear translocation of the nuclear factor (NF)-κB subunits p65 and p50 and AP-1 transcriptional factor c-Jun.
TC-E 5003 directly regulates c-Jun gene expression, and attenuates the activation of IκBα and Src in NF-κB signaling.

物理化学性质&存储条件

分子量	401.258
分子式	C16H14Cl2N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N'-(sulfonylbis(4,1-phenylene))bis(2-chloroacetamide)

参考文献

1. Eunji Kim, et al. Int J Mol Sci. 2020 Apr 26;21(9):3058.

2. Elisabeth-Maria Bissinger, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3717-31.

TC-E 5003 (TC-E5003)

生物&药学活性

物理化学性质&存储条件

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TC-E 5003 (TC-E5003)

生物&药学活性

物理化学性质&存储条件

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