TC-2153 |CAS:1381769-23-8 Probechem Biochemicals

Chemical Structure : TC-2153

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TC-2153 (TC2153)

货号: PC-62801Not For Human Use, Lab Use Only.

TC-2153 (TC2153) is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM.

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生物&药学活性

TC-2153 (TC2153) is a specific, small moelcule inhibitor of neuron-specific tyrosine phosphatase STEP with IC50 of 24.6 nM.
TC-2153 increases tyrosine phosphorylation of STEP substrates ERK1/2, Pyk2, and GluN2B, and exhibits no toxicity in cortical cultures.
TC-2153 shows specificity towards STEP compared to several other tyrosine phosphatases.
TC-2153 improves cognitive deficits in 3xTg-AD mice, with no change in beta amyloid and phospho-tau levels.

物理化学性质&存储条件

分子量	355.869
分子式	C7H5ClF3NS5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride

参考文献

1. Kulikov AV, et al. Psychopharmacology (Berl). 2012 Jun;221(3):469-78.

2. Xu J, et al. PLoS Biol. 2014 Aug 5;12(8):e1001923.

3. Baguley TD, et al. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1044-6.

4. Chatterjee M, et al. Neuropharmacology. 2018 Jan;128:43-53.

TC-2153 (TC2153)

生物&药学活性

物理化学性质&存储条件

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TC-2153 (TC2153)

生物&药学活性

物理化学性质&存储条件

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