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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-TBI-223
TBI-223

Chemical Structure : TBI-223

CAS No.: 2071265-08-0

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TBI-223 (TBI223)

货号: PC-20073Not For Human Use, Lab Use Only.

TBI-223 is an oxazolidinone with excellent oral bioavailability and activity against Gram-positive bacteria, works as protein synthesis inhibitor, targets an early step involving the binding of N-formylmethionyl-tRNA to the ribosome.

规格 价格 库存 数量
5 mg ￥3580 In stock
10 mg ￥5580 In stock
25 mg ￥8980 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TBI-223 is an oxazolidinone with excellent oral bioavailability and activity against Gram-positive bacteria, works as protein synthesis inhibitor, targets an early step involving the binding of N-formylmethionyl-tRNA to the ribosome.
TBI-223 showed reduced human and mouse bone marrow progenitor cell toxicity in vitro and bone marrow toxicity in rat and dog models in vivo, compared to linezolid.
TBI-223 had broader efficacy against other antibiotic-resistant Gram-positive bacteria, including vancomycin-resistant enterococci, penicillin- and ceftriaxone-resistant Streptococcus pneumoniae, and coagulase-negative staphylococci
TBI-223 had activity in vitro and in vivo against other bacteria, such as drug-sensitive and drug-resistant Mycobacterium tuberculosis.
TBI-223 had significant efficacy against MRSA infections, including in bacteremia, nondiabetic and diabetic skin wound infections, and OIAI.
TBI-223 had efficacy comparable to that of linezolid in all of the mouse models of bacteremia, nondiabetic and diabetic skin wound models, and OIAI.

物理化学性质&存储条件

分子量 365.36
分子式 C17H20FN3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

methyl (S)-((3-(3-fluoro-4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)carbamate

参考文献

1. Gordon O, et al. Microbiol Spectr. 2022 Oct 26;10(5):e0245121.

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