欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-TBI-166
TBI-166

Chemical Structure : TBI-166

CAS No.: 2377282-66-9

加入收藏

TBI-166 (TBI 166)

货号: PC-20072Not For Human Use, Lab Use Only.

TBI-166 is a potential next-generation antituberculosis riminophenazine with activity against Mycobacterium tuberculosis (0.063  μg/ml).

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TBI-166 is a potential next-generation antituberculosis riminophenazine with activity against Mycobacterium tuberculosis (0.063  μg/ml).
    TBI-166 shows MICs against 16 drug-sensitive clinical isolates range from <0.005 to 0.15 μg/ml, lower than those for clofazimine (CFZ) (0.026 to 0.633 μg/ml).
    TBI-166 maintained activity against Mycobacterium fortuitum and Mycobacterium scrofulaceum despite having higher MICs.
    TBI-166 exhibited activity against M. tuberculosis H37Rv infecting J774A.1 cells with CFU reductions of 0.54, 0.61, and 1.13 log10 at concentrations of 0.0625, 0.25, and 1 μg/ml, respectively.
    TBI-166 demonstrated activity at least equivalent to that of CFZ against intracellular M. tuberculosis and in low-dose aerosol infection models of acute and chronic murine tuberculosis.

    物理化学性质&存储条件

    分子量 589.62
    分子式 C32H30F3N5O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-3-((4-methoxycyclohexyl)imino)-N-(2-methoxypyridin-3-yl)-5-(4-(trifluoromethoxy)phenyl)-3,5-dihydrophenazin-2-amine

    参考文献

    1. Xu J, et al. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e02155-18.

    2. Zhang Y, et al. Antimicrob Agents Chemother. 2019 Jun 24;63(7):e02496-18.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: