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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-TBHQ
TBHQ

Chemical Structure : TBHQ

CAS No.: 1948-33-0

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TBHQ (tert-Butylhydroquinone)

货号: PC-42172Not For Human Use, Lab Use Only.

TBHQ (tert-Butylhydroquinone) is a phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TBHQ (tert-Butylhydroquinone) is a phenolic antioxidant and a selective inducer and activator of Nrf2 that ameliorates doxorubicin-induced cardiotoxicity in vivo.
TBHQ ameliorates the doxorubicin-induced oxidative stress and apoptosis, increases the nuclear accumulation of Nrf2 and the Nrf2-regulated gene expression, including HO-1 and NQO-1 expression.
TBHQ also ameliorates early brain injury after experimental subarachnoid emorrhage in mice by enhancing Nrf2-independent autophagy.

物理化学性质&存储条件

分子量 166.217
分子式 C10H14O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,4-Benzenediol, 2-(1,1-dimethylethyl)-

参考文献

1. Lin H, et al. Mol Pharmacol. 2014 May;85(5):682-91.

2. Wang LF, et al. Am J Transl Res. 2015 Oct 15;7(10):1724-35.

3. Li T, et al. Neurochem Res. 2015 Sep;40(9):1829-38.

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