TBC3486 |CAS:247044-77-5 Probechem Biochemicals

Chemical Structure : TBC3486

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TBC3486 (TBC-3486;TBC 3486)

货号: PC-61261Not For Human Use, Lab Use Only.

TBC3486 is a potent, selective, non-peptidic integrin α4β1 (VLA-4) antagonist with IC50 of 9 nM, displays 200-fold selectivity over α4β7 (IC50=2.1 uM).

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生物&药学活性

TBC3486 is a potent, selective, non-peptidic integrin α4β1 (VLA-4) antagonist with IC50 of 9 nM, displays 200-fold selectivity over α4β7 (IC50=2.1 uM).
TBC3486 mimics VCAM-1 binding, preferentially inhibits the high-affinity form of the integrin α4, blocks integrin-dependent T-cell co-activation in vitro as well as proves to be efficacious in vivo at low doses in animal models of allergic inflammation.
TBC3486 dose-dependently inhibits adhesion of ALL cells, prolongs the survival of xenotolerant mice bearing human leukemia cells in vivo.

物理化学性质&存储条件

分子量	557.68
分子式	C27H31N3O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-(benzo[d][1,3]dioxol-5-yl)-3-(3-((S)-1-(bis(thiophen-2-ylmethyl)amino)-1-oxohexan-2-yl)ureido)propanoic acid

参考文献

1. Hsieh YT, et al. Leukemia. 2014 Oct;28(10):2101-4.

2. Vanderslice P, et al. Biochem Biophys Res Commun. 2010 Oct 1;400(4):619-24.

TBC3486 (TBC-3486;TBC 3486)

生物&药学活性

物理化学性质&存储条件

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TBC3486 (TBC-3486;TBC 3486)

生物&药学活性

物理化学性质&存储条件

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