TB-03 |CAS:491831-49-3 Probechem Biochemicals

Chemical Structure : TB-03

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TB-03 (Grb2 SH2 inhibitor TB03)

货号: PC-61262Not For Human Use, Lab Use Only.

TB-03 is a small molecule Grb2 SH2 domain binding antagonist that synergistically enhances inhibition of K562 leukemia cell proliferation by imatinib (CI=0.774).

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生物&药学活性

TB-03 is a small molecule Grb2 SH2 domain binding antagonist that synergistically enhances inhibition of K562 leukemia cell proliferation by imatinib (CI=0.774).
TB-03 does not not affect apoptosis alone, enhances imatinib-induced apoptosis and cell cycle suppression, induction of apoptosi.
TB-03 reduced protein tyrosyl phosphorylation and Grb2 recruitment, suppression of a progenitor/stem cell subpopulation and increased expression of relevant tumor suppressor microRNAs.

物理化学性质&存储条件

分子量	708.749
分子式	C36H45N4O9P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-((1-(((S)-4-amino-1-((3-(naphthalen-1-yl)propyl)amino)-1,4-dioxobutan-2-yl)carbamoyl)cyclohexyl)amino)-4-oxo-3-(4-(phosphonomethyl)benzyl)butanoic acid

参考文献

1. Zhang M, et al. Leukemia. 2014 Apr;28(4):948-51.

TB-03 (Grb2 SH2 inhibitor TB03)

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TB-03 (Grb2 SH2 inhibitor TB03)

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物理化学性质&存储条件

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