TASP 0433864 | mGlu2 PAM | Probechem Biochemicals

Chemical Structure : TASP0433864

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TASP0433864 (TASP-0433864)

货号: PC-60822Not For Human Use, Lab Use Only.

TASP0433864 is a potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity.

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生物&药学活性

TASP0433864 is a potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity.
TASP0433864 has negligible activities for other mGlu receptors, including mGlu3 receptor.
TASP0433864 potentiates the mGlu2 receptor-mediated presynaptic inhibition of glutamate release, inhibits both MK-801- and ketamine-increased cortical γ band oscillation in the rat cortical electroencephalogram.
TASP0433864 significantly inhibits both ketamine- and methamphetamine-increased locomotor activities in mice.

物理化学性质&存储条件

分子量	329.4
分子式	C18H23N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-[(4-tert-butylphenoxy)methyl]-5-methyl-2,3-dihydroimidazo[2,1-b][1,3]oxazole-6-carboxamide

参考文献

1. Hiyoshi T, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):642-53.

TASP0433864 (TASP-0433864)

生物&药学活性

物理化学性质&存储条件

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TASP0433864 (TASP-0433864)

生物&药学活性

物理化学性质&存储条件

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