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首页-小分子抑制剂&激动剂-TGF-beta/Smad-TGF beta Receptor (TGFBR)-TASP0382088
TASP0382088

Chemical Structure : TASP0382088

CAS No.: 1253941-85-3

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TASP0382088 (TASP-0382088)

货号: PC-61455Not For Human Use, Lab Use Only.

TASP0382088 is a potent, selective ALK5 inhibitor with IC50 of 4.8 nM, >100-fold selectivity over 95 different kinases.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TASP0382088 is a potent, selective ALK5 inhibitor with IC50 of 4.8 nM, >100-fold selectivity over 95 different kinases.
    TASP0382088 inhibits TGF-β-induced Smad2/3 phosphorylation at cellular level with IC50 of 17 nM.
    TASP0382088 inhibits Smad2 phosphorylation in mouse skin after topical application.

    物理化学性质&存储条件

    分子量 328.408
    分子式 C15H12N4OS2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-Methoxy-6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole

    参考文献

    1. Amada H, et al. Chem Pharm Bull (Tokyo). 2013;61(3):286-91.

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