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首页-小分子抑制剂&激动剂-GPCR-Prostaglandin Receptor-TASP0376377
TASP0376377

Chemical Structure : TASP0376377

CAS No.: 1233246-60-0

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TASP0376377 (TASP 0376377)

货号: PC-61564Not For Human Use, Lab Use Only.

TASP0376377 is a potent, selective prostaglandin D2 receptor (CRTH2) antagonist with binding IC50 of 19 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    TASP0376377 is a potent, selective prostaglandin D2 receptor (CRTH2) antagonist with binding IC50 of 19 nM.
    TASP0376377 shows excellent functional antagonist activity in chemotaxis assay with IC50 of 23 nM, displays sufficient selectivity for binding to CRTH2 over the DP1 prostanoid receptor (IC50>1 yM), COX-1 and COX-2 enzymes (IC50>10 uM).

    物理化学性质&存储条件

    分子量 479.313
    分子式 C25H16Cl2N2O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(1-(4-(3,4-dichlorobenzamido)benzoyl)isoquinolin-4-yl)acetic acid

    参考文献

    1. Nishikawa-Shimono R, et al. Bioorg Med Chem Lett. 2012 May 1;22(9):3305-10.

    2. Nishikawa-Shimono R, et al. Bioorg Med Chem. 2013 Dec 15;21(24):7674-85.

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