TASK inhibitor F3

Chemical Structure : TASK inhibitor F3

CAS No.: 600125-11-9

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货号: PC-49468Not For Human Use, Lab Use Only.

TASK inhibitor F3 is a potent, selective blocker of TWIK-related acid-sensitive K+ (TASK) channels with IC50 of 148 nM (TASK-1).

规格	价格	库存
10 mg	￥1380	In stock
25 mg	￥2280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TASK inhibitor F3 is a potent, selective blocker of TWIK-related acid-sensitive K+ (TASK) channels with IC50 of 148 nM (TASK-1).
TASK inhibitor F3 displays a reduced inhibition of TASK-3 channels and not a significant effect on different K+ channels.
TASK inhibitor F3 blocks cell proliferation and viability in the MCF-7 cancer cell line but not in TASK-1 knockdown MCF-7 cells.
Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels.

物理化学性质&存储条件

分子量	344.414
分子式	C22H20N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-benzamido-N-(2-ethylphenyl)benzamide

参考文献

1. Bárbara Arévalo, et al. J. Med. Chem. 2022.