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TASIN-1

Chemical Structure : TASIN-1

CAS No.: 792927-06-1

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TASIN-1 (Truncated APC selective inhibitor-1)

货号: PC-72962Not For Human Use, Lab Use Only.

TASIN-1 (Truncated APC selective inhibitor-1) is a small molecule that specifically kills cells with APC truncations but spares normal and cancer cells with wild-type APC, inhibits emopamil-binding protein (EBP).

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TASIN-1 (Truncated APC selective inhibitor-1) is a small molecule that specifically kills cells with APC truncations but spares normal and cancer cells with wild-type APC, inhibits emopamil-binding protein (EBP).
TASIN-1 exhibited potent and selective toxicity toward DLD1 cells (IC50 = 70 nM) but not toward HCT116 cells (IC50 > 50 μM).
TASIN-1 decreased the endogenous cholesterol biosynthesis rate in APC-truncated HT29 and DLD1 cells but not in APC WT HCT116 and RKO cells, TASIN-1 exerts its cytotoxicity through inhibition of cholesterol biosynthesis.
TASIN-1 inhibits emopamil-binding protein (EBP) or 24-dehydrocholesterol reductase (DHCR24).

物理化学性质&存储条件

分子量 352.493
分子式 C18H28N2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1'-((4-methoxyphenyl)sulfonyl)-4-methyl-1,4'-bipiperidine

参考文献

1. Zhang L, et al. Sci Transl Med. 2016 Oct 19;8(361):361ra140.

2. Zhang L, et al. Mol Cancer Ther. 2018 May;17(5):943-951.

3. Wang W, et al. J Med Chem. 2019 May 23;62(10):5217-5241.

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