TAS0612 | YBX1 inhibitor | Probechem Biochemicals

Chemical Structure : TAS0612

CAS No.: 2148902-58-1

加入收藏

TAS0612 (TAS-0612)

货号: PC-38198Not For Human Use, Lab Use Only.

TAS0612 (TAS-0612) is an orally bioavailable multikinase inhibitor of AKT, p70S6K, and p90RSK, inhibits Y-box-binding protein (YBX1) phosphorylation.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TAS0612 (TAS-0612) is an orally bioavailable multikinase inhibitor of AKT, p70S6K, and p90RSK, inhibits Y-box-binding protein (YBX1) phosphorylation.
TAS0612 inhibits cell proliferation and suppresses the phosphorylation of YBX1 in TNBC cell lines, shows antitumor effect against antiestrogen-resistant cells and TNBC cells in vivo.
TAS0612 inhibited pYBX1, pPRAS40 and pS6 in ERα(+)/HER2(−) and ERα(−)/HER2(+) cell lines, the expression levels of pAKT, pp90RSK, and pp70S6K were increased following treatment with relatively higher doses of TAS0612.
TAS0612 showed potent antitumor effects and marked inhibition of pYBX1 and pS6 in the experimental therapeutic model of TNBC.

物理化学性质&存储条件

分子量	573.61
分子式	C27H34F3N9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(3-((2-(tert-butylamino)ethyl)amino)-6-(5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl)pyridin-2-yl)piperidin-1-yl)-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

参考文献

1. Shibata T, et al. Mol Cancer Ther. 2020 Mar;19(3):882-894.

TAS0612 (TAS-0612)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TAS0612 (TAS-0612)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.