TAS05567 |CAS:1429038-15-2 Probechem Biochemicals

Chemical Structure : TAS05567

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TAS05567 (TAS 05567;TAS-05567;TAS-5567)

货号: PC-63503Not For Human Use, Lab Use Only.

TAS05567 (TAS-5567) is a novel potent, selective, orally available Spleen tyrosine kinase (Syk) inhibitor with IC50 of 0.37 nM.

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生物&药学活性

TAS05567 (TAS-5567) is a novel potent, selective, orally available Spleen tyrosine kinase (Syk) inhibitor with IC50 of 0.37 nM.
TAS05567 shows >70% inhibition of Syk and 4 other kinases in a panel of 192 kinases, more selective and potent than R406.
TAS05567 suppresses induction of BLNK phosphorylation by anti-IgM in Ramos cells (IC50=1.8 nM).
TAS05567 inhibits BCR-dependent signal transduction in Ramos cells, FcγR-mediated TNF-α production in THP-1 cells, and FcεR-mediated histamine release from RBL-2H3 cells.
TAS05567 suppresses hind-paw swelling in a dose-dependent manner, markedly reduces histopathologic scores in rheumatoid arthritis models.

物理化学性质&存储条件

分子量	439.524
分子式	C21H29N9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(((3R,4R)-3-aminotetrahydro-2H-pyran-4-yl)amino)-5-((2-(tert-butyl)-7-methyl-2H-indazol-5-yl)amino)-1,2,4-triazine-6-carboxamide

参考文献

1. Hayashi H, et al. J Pharmacol Exp Ther. 2018 May 4. pii: jpet.118.248153.

TAS05567 (TAS 05567;TAS-05567;TAS-5567)

生物&药学活性

物理化学性质&存储条件

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TAS05567 (TAS 05567;TAS-05567;TAS-5567)

生物&药学活性

物理化学性质&存储条件

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