TAS-117 hydrochloride |CAS: 2930090-28-9 Probechem Biochemicals

Chemical Structure : TAS-117 hydrochloride

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TAS-117 hydrochloride (Pifusertib, TAS117)

货号: PC-63553Not For Human Use, Lab Use Only.

TAS-117 (Pifusertib) hydrochloride is a highly selective, oral, allosteric pan-AKT inhibitor with IC50 of 4.8/1.6/44 nM for Akt1/Akt2/Akt3 respectively.

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生物&药学活性

TAS-117 (Pifusertib) hydrochloride is a highly selective, oral, allosteric pan-AKT inhibitor with IC50 of 4.8/1.6/44 nM for Akt1/Akt2/Akt3 respectively.
TAS-117 (Pifusertib) shows minimal inhibitory activities against others kinases including PI3K, PDK1, and mTOR.
TAS-117 (Pifusertib) inhibits Akt kinase activity but not p-Akt, blocks basal phosphorylation of Akt and downstream p-FKHR/FKHRL1.
TAS-117 (Pifusertib) induces significant cytotoxicity in MM cells associated with inhibition of IL6 secretion.
TAS-117 (Pifusertib) triggers apoptosis and autophagy, induces ER stress response, inhibits human MM cell growth in murine xenograft models.

物理化学性质&存储条件

分子量	460.962
分子式	C26H25ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Trans-3-amino-1methyl-3-[4-(3-phenyl-5H- imidazo[1,2-c]pyrido[3,4-e][1,3]oxazin-2-yl)phenyl]-cyclobutanol hydrochloride

参考文献

1. Mimura N, et al. Cancer Res. 2014 Aug 15;74(16):4458-69.

TAS-117 hydrochloride (Pifusertib, TAS117)

生物&药学活性

物理化学性质&存储条件

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TAS-117 hydrochloride (Pifusertib, TAS117)

生物&药学活性

物理化学性质&存储条件

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