TAS-114 | dUTPase/DPD inhibitor | Probechem Biochemicals

Chemical Structure : TAS-114

CAS No.: 1198221-21-4

加入收藏

TAS-114 (TAS114)

货号: PC-63498Not For Human Use, Lab Use Only.

TAS-114 is a first-in-class, potent, dual dUTPase/DPD (dihydropyrimidine dehydrogenase) inhibitor with Ki of 0.13/2.14 uM, respectively.

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2880	In stock
25 mg	￥4980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

TAS-114 is a first-in-class, potent, dual dUTPase/DPD (dihydropyrimidine dehydrogenase) inhibitor with Ki of 0.13/2.14 uM, respectively.

TAS-114 competitively inhibits dUTPase in the dUTP binding step, selectively inhibits the hydrolysis of dUTP to dUMP in cancer cells, significantly enhances cytotoxicity of fluoropyrimidines.

TAS-114 has moderate and reversible inhibitory activity on dihydropyrimidine dehydrogenase (DPD), a catabolizing enzyme of 5-FU; increases the bioavailability of 5-FU when co-administered with capecitabine in mice, significantly improves the therapeutic efficacy of capecitabine in vivo.

物理化学性质&存储条件

分子量	451.538
分子式	C21H29N3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1R)-1-[3-(cyclopentyloxy)phenyl]-ethyl]-3-[(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)methoxy]-1-propanesulfonamide

参考文献

1. Yano W, et al. Mol Cancer Ther. 2018 May 10. pii: molcanther.0911.2017.

2. Saito K, et al. Cancer Chemother Pharmacol. 2014 Mar;73(3):577-83.

TAS-114 (TAS114)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

TAS-114 (TAS114)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.