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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Topoisomerase-TAS-103 dihydrochloride
TAS-103 dihydrochloride

Chemical Structure : TAS-103 dihydrochloride

CAS No.: 174634-09-4

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TAS-103 dihydrochloride (BMS-247615 dihydrochloride)

货号: PC-25320Not For Human Use, Lab Use Only.

TAS-103 dihydrochloride (BMS-247615) is an effective small molecule inhibitor of topoisomerases I and II (Topo I and Topo II) with IC50 of 2 uM and 6.5 uM, shows cytotoxic effect on P388 and KB cells with IC50 of 1.1 nM and 9.6 nM respectively.

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10 mg ￥1280 In stock
25 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TAS-103 dihydrochloride (BMS-247615) is an effective small molecule inhibitor of topoisomerases I and II (Topo I and Topo II) with IC50 of 2 uM and 6.5 uM, shows cytotoxic effect on P388 and KB cells with IC50 of 1.1 nM and 9.6 nM respectively.

物理化学性质&存储条件

分子量 406.31
分子式 C20H21Cl2N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-((2-(Dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride

参考文献

1. Aoyagi Y, et al. Jpn J Cancer Res. 1999 May;90(5):578-87.

2. Utsugi T, et al. Jpn J Cancer Res. 1997 Oct;88(10):992-1002.

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