TAP311 | CETP inhibitor | Probechem Biochemicals

Chemical Structure : TAP-311

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TAP-311 (TAP311)

货号: PC-62014Not For Human Use, Lab Use Only.

TAP-311 (TAP311) is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM.

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生物&药学活性

TAP-311 (TAP311) is a novel potent and selective CETP inhibitor with plasma IC50 of 62 nM.
TAP-311 displays >170-fold selectivity over CYPs, and has excellent pharmacokinetics in rats and robust efficacy in hamsters.
TAP-311 shows substantially reduced lipophilicity with only modest distribution into adipose tissue, and retains potency in hypertriglyceridemic plasma in vitro and in vivo.
TAP-311 does not increase blood pressure or plasma aldosterone levels in vivo, in contrast to torcetrapib (Cat# PC-42892).

物理化学性质&存储条件

分子量	710.72
分子式	C34H40F6N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((4-((3,5-bis(trifluoromethyl)benzyl)(5-(1-methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)-2,6-diethylpiperidine-1-carbonyl)oxy)cyclohexane-1-carboxylic acid

参考文献

1. Yamada K, et al. J Med Chem. 2017 Oct 26;60(20):8466-8481.

TAP-311 (TAP311)

生物&药学活性

物理化学性质&存储条件

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TAP-311 (TAP311)

生物&药学活性

物理化学性质&存储条件

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