TAOK inhibitor 63 |CAS:850467-91-3 Probechem Biochemicals

Chemical Structure : TAOK inhibitor 63

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TAOK inhibitor 63

货号: PC-62818Not For Human Use, Lab Use Only.

TAOK inhibitor 63 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 19 and 39 nM against TAOK1 (MAP3K16) and TAOK2 (MAP3K17), respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

TAOK inhibitor 63 is a novel potent, selective, ATP-competitive TAO Kinase (TAOK) inhibitor with IC50 of 19 and 39 nM against TAOK1 (MAP3K16) and TAOK2 (MAP3K17), respectively.
TAOK inhibitor 63 increases the mitotic population, the percentages of mitotic cells displaying amplified centrosomes and multipolar spindle.
TAOK inhibitor 63 induces cell death, and inhibits cell growth in centrosome-amplified SKBR3 or BT549 breast cancer cell models.

物理化学性质&存储条件

分子量	488.562
分子式	C26H24N4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-{3-[(2-{[6-methoxy-1,3-benzothiazol-2-yl]amino}-2-oxoethyl)amino]-3-oxo-1-phenylpropyl}benzamide

参考文献

1. Koo CY, et al. Mol Cancer Ther. 2017 Nov;16(11):2410-2421.