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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-TAM-16
TAM-16

Chemical Structure : TAM-16

CAS No.: 2030241-59-7

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TAM-16 (TAM16, TAM 16)

货号: PC-60356Not For Human Use, Lab Use Only.

TAM-16 is a benzofuran class inhibitor of M. tuberculosis Pks13 (Polyketide Synthase 13 with IC50 of 0.32 uM.

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5 mg ￥1480 In stock
10 mg ￥2280 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TAM-16 is a benzofuran class inhibitor of M. tuberculosis Pks13 (Polyketide Synthase 13 with IC50 of 0.32 uM.
TAM-16 show highly potent in vitro bactericidal activity against drug-susceptible and drug-resistant clinical isolates of M. tuberculosis (MICs: 0.06-0.25 uM).
TAM-16 exhibits in vivo efficacy in multiple mouse models of TB infection, has excellent pharmacological and safety profiles.

物理化学性质&存储条件

分子量 380.444
分子式 C22H24N2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-hydroxy-2-(4-hydroxyphenyl)-N-methyl-4-(piperidin-1-ylmethyl)-2,3-dihydrobenzofuran-3-carboxamide

参考文献

1. Aggarwal A, et al. Cell. 2017 Jul 13;170(2):249-259.e25.

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