TAK-931 |CAS:1330782-76-7 Probechem Biochemicals

Chemical Structure : TAK-931

CAS No.: 1330782-76-7

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TAK-931 (Simurosertib;TAK931)

货号: PC-63139Not For Human Use, Lab Use Only.

TAK-931 (Simurosertib) is a potent, selective, ATP competitive and orally bioavailable inhibitor of Cdc7 with IC50 of <0.3 nM.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4780	In stock
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100 mg		Get quote

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生物&药学活性

TAK-931 (Simurosertib) is a potent, selective, ATP competitive and orally bioavailable inhibitor of Cdc7 with IC50 of <0.3 nM.
TAK-931 prevents the initiation of DNA replication during mitosis, which causes cell cycle arrest and induces apoptosis.
TAK-931 demonstrates antiproliferative activity with cancer cell lines and tumor growth inhibition (TGI) in murine ectopic xenograft models.

物理化学性质&存储条件

分子量	341.433
分子式	C17H19N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Thieno[3,2-d]pyrimidin-4(3H)-one, 2-(2S)-1-azabicyclo[2.2.2]oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-

参考文献

1. Charles Locuson, et al. Abstract 5041: Translational pharmacokinetic-pharmacodynamic xenograft model for TAK-931, a small molecule cell division cycle 7 (CDC7) kinase inhibitor. AACR.

2. Kenichi Iwai, et al. Abstract 3073: Potential predictive biomarkers of clinical responses for a novel CDC7-selective inhibitor TAK-931. AACR.

TAK-931 (Simurosertib;TAK931)

生物&药学活性

物理化学性质&存储条件

参考文献

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TAK-931 (Simurosertib;TAK931)

生物&药学活性

物理化学性质&存储条件

参考文献

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