TAK-925 (Danavorexton) | OX2R agonist | Probechem Biochemicals

Chemical Structure : TAK-925

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TAK-925 (Danavorexton, TAK925)

货号: PC-72749Not For Human Use, Lab Use Only.

TAK-925 (Danavorexton) is a potent, selective, and brain-penetrant Orexin 2 receptor (OX2R) agonist with EC50 of 5.5 nM, no significant inhibition on OX1R (IC50>100 uM).

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生物&药学活性

TAK-925 (Danavorexton) is a potent, selective, and brain-penetrant Orexin 2 receptor (OX2R) agonist with EC50 of 5.5 nM, no significant inhibition on OX1R (IC50>100 uM).
TAK-925 also showed good selectivity against 106 off-target enzymes and receptors.
TAK-925 produced wake-promoting effects in mice during the sleep phase, being developed for the treatment of narcolepsy and other related disorders.

物理化学性质&存储条件

分子量	424.556
分子式	C21H32N2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperidinecarboxylic acid, 3-[(methylsulfonyl)amino]-2-[[(cis-4-phenylcyclohexyl)oxy]methyl]-, methyl ester, (2R,3S)-

参考文献

1. Fujimoto T, et al. ACS Med Chem Lett. 2022 Feb 4;13(3):457-462.

2. Yukitake H, et al. Pharmacol Biochem Behav. 2019 Dec;187:172794.

TAK-925 (Danavorexton, TAK925)

生物&药学活性

物理化学性质&存储条件

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TAK-925 (Danavorexton, TAK925)

生物&药学活性

物理化学性质&存储条件

参考文献

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