TAK-915 |CAS:1476727-50-0 Probechem Biochemicals

Chemical Structure : TAK-915

CAS No.: 1476727-50-0

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TAK-915 (TAK915;TAK 915)

货号: PC-60563Not For Human Use, Lab Use Only.

TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM.

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2 mg	￥4580	In stock
5 mg	￥7580	In stock
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生物&药学活性

TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM.
TAK-915 dispalys 4100-fold selectivity over PDE1A, and >20,000-fold over other PDE isoforms.
TAK-915 robustly increased cGMP levels in the rat brain, attenuates MK-801-induced episodic memory deficits in rats.

物理化学性质&存储条件

分子量	458.37
分子式	C19H18F4N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((1S)-1-(3-fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide

参考文献

1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702.

TAK-915 (TAK915;TAK 915)

生物&药学活性

物理化学性质&存储条件

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TAK-915 (TAK915;TAK 915)

生物&药学活性

物理化学性质&存储条件

参考文献

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