TAK-733 |CAS:1035555-63-5 Probechem Biochemicals

Chemical Structure : TAK-733

CAS No.: 1035555-63-5

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TAK-733 (TAK733;TAK 733)

货号: PC-43541Not For Human Use, Lab Use Only.

TAK-733 (TAK733,TAK 733) is a potent, selective, allosteric inhibitor of MEK with IC50 of 3.2 nM (MEK1).

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5 mg	￥1180	In stock
25 mg	￥3280	In stock
100 mg	￥7980	In stock
500 mg		Get quote

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生物&药学活性

TAK-733 (TAK733,TAK 733) is a potent, selective, allosteric inhibitor of MEK with IC50 of 3.2 nM (MEK1).
TAK-733 shows selectivity for MEK1 over a panel of 18 kinases, receptors, and ion channels at 1 uM.
TAK-733 inhibits ERK phosphorylation in vitro with EC50 of 1.9 nM, also inhibits proliferation of A375 and COLO 205 cells with IC50 of 3.1 nM and 2.1 nM, respectively.
TAK-733 demonstrates antitumor activity in multiple mouse xenograft models.

物理化学性质&存储条件

分子量	504.2267
分子式	C17H15F2IN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methyl-

参考文献

1. Dong Q, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1315-9.

2. von Euw E, et al. Mol Cancer. 2012 Apr 19;11:22.

3. Dahlman KB, et al. Cancer Discov. 2012 Sep;2(9):791-7.

4. Micel LN, et al. Mol Cancer Ther. 2015 Feb;14(2):317-25.

TAK-733 (TAK733;TAK 733)

生物&药学活性

物理化学性质&存储条件

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TAK-733 (TAK733;TAK 733)

生物&药学活性

物理化学性质&存储条件

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