TAK-715 | p38α inhibitor, CK1δ/ε inhibitor | Probechem Biochemicals

Chemical Structure : TAK-715

CAS No.: 303162-79-0

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TAK-715 (TAK 715, TAK715)

货号: PC-42599Not For Human Use, Lab Use Only.

TAK-715 is a potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM, also inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

TAK-715 is a potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM, also inhibits casein kinase I (CK1δ/ε) to regulate activation of Wnt/β-catenin signaling.
TAK-715 displays >20-fold selectvity over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
TAK-715 inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48 nM.
TAK-715 exerts significant efficacy in rat adjuvant-induced arthritis model.

物理化学性质&存储条件

分子量	399.508
分子式	C24H21N3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-

参考文献

1. Miwatashi S, et al. J Med Chem. 2005 Sep 22;48(19):5966-79.

2. Verkaar F, et al. Chem Biol. 2011 Apr 22;18(4):485-94.

TAK-715 (TAK 715, TAK715)

生物&药学活性

物理化学性质&存储条件

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TAK-715 (TAK 715, TAK715)

生物&药学活性

物理化学性质&存储条件

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