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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-TAK-715
TAK-715

Chemical Structure : TAK-715

CAS No.: 303162-79-0

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TAK-715 (TAK 715, TAK715)

货号: PC-42599Not For Human Use, Lab Use Only.

TAK-715 is a potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥2880 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

TAK-715 is a potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM.
TAK-715 displays >20-fold selectvity over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1.
TAK-715 inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48 nM.
TAK-715 exerts significant efficacy in rat adjuvant-induced arthritis model.

物理化学性质&存储条件

分子量 399.508
分子式 C24H21N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]-

参考文献

1. Miwatashi S, et al. J Med Chem. 2005 Sep 22;48(19):5966-79.

2. Verkaar F, et al. Chem Biol. 2011 Apr 22;18(4):485-94.

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